Service Providers for PMS2
PMS2 (Postmeiotic Segregation Increased 2) is a gene that plays a crucial role in the DNA mismatch repair (MMR) system. It helps maintain genomic stability by correcting errors that occur during DNA replication. Mutations in PMS2 can lead to Lynch syndrome (also known as hereditary non-polyposis colorectal cancer, or HNPCC), an inherited condition that increases the risk of developing colorectal cancer and other cancers, such as endometrial, ovarian, and stomach cancer. PMS2 mutations impair the MMR system, allowing genetic mutations to accumulate in cells, potentially leading to cancer. Testing for PMS2 mutations can be important for individuals with a family history of cancer to assess risk and guide surveillance strategies.